After celebrating Doug's upcoming wedding in a cut rate hotel in Laughlin, NV, hungover guys Bradley, Ed and Zach wake up in a futuristic dystopia, having lost their pal, Doug. With the help of Effing and Justmitch, the trio's loyal advisers, the gang must now prepare to battle their way through the pop culture districts of The Hungover Games including The Real Housewives of District 8 and Teddy from The Puppet District.

While traveling through the desert nearby the small town of Santa Ynez on their bicycles to camp, two teenage bicyclers are murdered by a mysterious black car. Then the car hit-and-run a hitchhiker and the crime is witnessed by the local Amos Clements. Sheriff Everett puts his men in alert and plans road blocks in the area to arrest the murderer. Sooner he becomes a victim of the car and Sheriff Wade Parent begins a hunting of the vehicle that is threatening his town and seems to be impossible to be located. When his beloved girlfriend and teacher Lauren challenges the driver in a cemetery, the car hunts her in her home and Wade realizes that he might be dealing with supernatural powers.